Common Name Minoxidil
CAS Number 38304-91-5
Molecular Weight 209.248
Density 1.5±0.1 g/cm3
Boiling Point 351.7±45.0 °C at 760 mmHg
Molecular Formula C9H15N5O
Melting Point 272-274 °C (dec.)(lit.)
Flash Point 166.5±28.7 °C
Exact Mass 209.127655
PSA 91.16000 LogP -1.49
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.724
Storage condition Store at RT
Use of Minoxidil
Minoxidil(U 10858) is an antihypertensive vasodilator medication. Target: potassium channel Minoxidil, a potent antihypertensive agent, induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. The pharmacologic mechanisms by which minoxidil stimulates hair growth are unknown. This study was designed to examine whether minoxidil has direct effects on neonatal murine epidermal cells in culture. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation. In addition, two morphologically distinct cell types appeared. Indirect immunofluorescence staining with keratin-specific antibody revealed cytoplasmic keratin fibers, suggesting the epidermal origin of these cells. Our experiments demonstrate that minoxidil can affect epidermal cells in culture by altering their growth pattern and phenotypic appearance [1] . Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h [2].
Solubility 1 mM 4.7790 mL 23.8949 mL 47.7897 mL 5 mM 0.9558 mL 4.7790 mL 9.5579 mL 10 mM 0.4779 mL 2.3895 mL 4.7790 mL
Storage Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
Synonyms
Regaine |
EINECS 253-874-2 |
2,4-diamino-6-piperidino-pyrimidine-3-oxide |
2,6-Diamino-4-piperidinopyrimidine 1-Oxide |
Rogaine |
4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-, (2E)- |
MFCD00063409 |
Theroxidil |
3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine |
Tricoxidil |
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide |
Lonolox |
(2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol |
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide (6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide |
2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide |
Alostil |
Loniten |
Minoximen |
Post time: Jul-26-2022