API Circulatory system medication Prevention and treatment of angina pectoris Minoxidil

Common Name Minoxidil

CAS Number 38304-91-5

Molecular Weight 209.248

Density 1.5±0.1 g/cm3

Boiling Point 351.7±45.0 °C at 760 mmHg

Molecular Formula C9H15N5O

Melting Point 272-274 °C (dec.)(lit.)

Flash Point 166.5±28.7 °C

Exact Mass 209.127655

PSA 91.16000 LogP -1.49

Vapour Pressure 0.0±1.8 mmHg at 25°C

Index of Refraction 1.724

Storage condition Store at RT

 

Use of Minoxidil

Minoxidil(U 10858) is an antihypertensive vasodilator medication. Target: potassium channel Minoxidil, a potent antihypertensive agent, induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. The pharmacologic mechanisms by which minoxidil stimulates hair growth are unknown. This study was designed to examine whether minoxidil has direct effects on neonatal murine epidermal cells in culture. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation. In addition, two morphologically distinct cell types appeared. Indirect immunofluorescence staining with keratin-specific antibody revealed cytoplasmic keratin fibers, suggesting the epidermal origin of these cells. Our experiments demonstrate that minoxidil can affect epidermal cells in culture by altering their growth pattern and phenotypic appearance [1] . Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h [2].

Solubility 1 mM 4.7790 mL 23.8949 mL 47.7897 mL 5 mM 0.9558 mL 4.7790 mL 9.5579 mL 10 mM 0.4779 mL 2.3895 mL 4.7790 mL

Storage Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping Room temperature in continental US; may vary elsewhere

 

Synonyms

Regaine
EINECS 253-874-2
2,4-diamino-6-piperidino-pyrimidine-3-oxide
2,6-Diamino-4-piperidinopyrimidine 1-Oxide
Rogaine
4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-, (2E)-
MFCD00063409
Theroxidil
3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
Tricoxidil
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
Lonolox
(2E)-6-Amino-2-imino-4-(1-piperidinyl)-1(2H)-pyrimidinol
6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide (6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide
Alostil
Loniten
Minoximen

Post time: Jul-26-2022