Levamisole Hydrochloride is the hydrochloride salt of the synthetic imidazothiazole derivative levamisole with anthelminthic and immunomodulating activities. In immunosuppressed states, levamisole may restore immune function by: 1) stimulating antibody formation, 2) stimulating T-cell activation and proliferation, 3) potentiating monocyte and macrophage phagocytosis and chemotaxis and 4) increasing neutrophil mobility, adherence, and chemotaxis.
Common Name Levamisole (hydrochloride)
CAS Number 16595-80-5
Molecular Weight 240.752
Boiling Point 344.4ºC at 760 mmHg
Molecular Formula C11H13ClN2S
Melting Point 226-231ºC
Use of Levamisole (hydrochloride)
Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging.
Storage Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
Synonyms
| (-)-Tetramisole hydrochloride |
| Solaskil |
| Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-, hydrochloride (1:1) |
| Spartakon |
| Levamisol hydrochloride |
| (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride |
| (6S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazolhydrochlorid |
| (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride |
| Ascaridil |
| Levasole |
| Meglum |
| Levadin |
| MFCD00005536 |
| (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride |
| L[-]-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole |
| (-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole monohydrochloride |
| Decaris |
| L-(-)-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride |
| (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole monohydrochloride |
| Nilverm |
| Ripercol |
| L(−)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole hydrochloride |
| Levamisole HCl |
| Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, L-(-)- |
| L-(-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride |
| EINECS 240-654-6 |
| Tramisol |
| (6S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride (1:1) |
| L-Tetramisole hydrochloride |
| Levamisole hydrochloride |
| Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, L-(-)- |
| Levacide |
| Ergamisol |
| Nemicide |
| (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride |
| Levamisole (hydrochloride) |
Post time: Aug-04-2022